 | Dr. Arthur L. Horwich |
Dr. Arthur L. Horwich, the newly appointed Eugene Higgins Professor of Cellular and Molecular Physiology, is a noted genetics researcher whose laboratory research is focused on specialized proteins called molecular chaperones.
Also an investigator at the Howard Hughes Medical Institute and a professor of pediatrics, Horwich is particularly concerned with exploring the mechanism of action of molecular chaperones in assisting protein folding in the cell. He has investigated the role of ring assemblies called chaperonins in mediating adenosine triphosphate (ATP)-dependent folding of proteins to their native forms, as well as the mechanism of protein misfolding that results in the formation of amyloids -- fibrillar structures formed in a class of neurodegenerative diseases, including Alzheimer's disease.
To understand how these and related compounds work, Horwich employs genetic analysis in vivo, as well as biochemical analyses in vitro, in addition to crystallographic analyses, fluorescence and nuclear magnetic resonance spectroscopy studies. He has published his research in more than 100 articles or papers in scientific journals.
Horwich earned his B.A. and M.D. degrees from Brown University and completed a pediatric internship and residency at Yale-New Haven Hospital. From 1978 to 1981, he was a postdoctoral fellow at the Salk Institute in La Jolla, California, where he worked with Walter Eckhart. He returned to New Haven in 1981 as a postdoctoral fellow in the School of Medicine's Department of Genetics, where he worked with Dr. Leon Rosenberg. He joined the Yale faculty in 1984 as an assistant professor in genetics, and was named a full professor in that department in 1995. He has been affiliated with the Howard Hughes Medical Institute since 1990.
Elected to the National Academy of Sciences this year, Horwich has also been honored with the Society for Pediatric Research's Outstanding Young Investigator Award and the Protein Society's Hans Neurath Award. He has received a number of research awards, including the March of Dimes Basil O'Connor Starter Research Grant.
The genetics researcher has served as the associate editor of the scientific publications Cell, Molecular Cell, Structure with Folding and Design, and Cell Stress and Chaperones. He has been on the editorial boards of Protein Science, the Journal of Cell Biology and Quarterly Review Biophysics.
Horwich is a member of the American Association for the Advancement of Science, the American Chemical Society, the American Society of Cell Biology, the American Society of Human Genetics and the Protein Society.
T H I S
Horwich is Higgins Professor of
Cellular, Molecular Physiology
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