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November 19, 2004|Volume 33, Number 12|Two-Week Issue



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Study will test drug's ability to reduce smokers' withdrawal symptoms

Yale researchers are conducting a study of a medication that could help reduce the withdrawal symptoms that might sabotage the efforts of people who are trying to quit smoking.

Andrea Weinberger, project director for the new trial, says dopamine levels in the brain might be part of the reason why withdrawal symptoms occur. The researchers will test the effectiveness of a monoamine oxidase B (MAO-B) inhibitor called Selegiline, which allows smokers who are trying to quit to maintain higher levels of dopamine.

"For some smokers, it might help them get through the withdrawal period," Weinberger says.

The study is seeking people who smoke at least 15 cigarettes a day and who have no major medical or current addictive or psychiatric illnesses. People enrolled in the study will undergo several screening sessions, including a full medical exam. Some smokers will then randomly receive the medication and some will receive a placebo, or inactive sugar pill. Smokers will not know which group they are in. All smokers will receive smoking cessation counseling on a weekly basis where they will get information on strategies for quitting, coping with withdrawal and cravings, and other relapse prevention techniques. Smokers will be asked to participate in the study for about 10 weeks, with periodic follow-ups for the next six months.

In addition to participating in the larger study, all smokers will be asked if they would like to be included in a related study that will try to find out more about how expectations affect smoking cessation.

"We will try to find out what they believe about the effect that smoking has on them and how these beliefs change over the course of an attempt to stop smoking," Weinberger says.

To learn more about the study, or to sign up, call (203) 974-7867.

Dr. Tony George, associate professor of psychiatry, is the principal investigator on this study. The studies are supported by a $1.5 million grant from the National Institute on Drug Abuse awarded to George, and a pilot project grant to Weinberger from the Transdisciplinary Tobacco Use Research Center, which is part of the Center for Nicotine and Tobacco Use Research at Yale.

-- By Pem McNerney


T H I SW E E K ' SS T O R I E S

Gift of equipment to further research in engineering

Students helping small businesses locally and globally

In Focus: Yale Medical Group

New center to foster joint study of ecology, epidemiology

Death rate rises in urban areas during the time . . .

Conference and exhibit to explore legacy of Napoleon

There's a clash of divas in the Yale Rep's 'The Ladies of the Camellias'

Painter of Chinese themes is named gallery's resident artist

Researchers identify a receptor in tick gut . . .

Scientists find link between early gambling . . .

Grant funds design of program to keep pregnant women off drugs

Study: Family history of alcoholism lowers brain's 'brake' on heavy drinking

Study will test drug's ability to reduce smokers' withdrawal symptoms

Memorial service for Osea Noss

Campus Notes


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