research collaborations
The School of Medicine and Boehringer Ingelheim Pharmaceuticals Inc. (BIPI) have established a Research Alliance Agreement to support translational cardiovascular and immunology research.
The alliance between Yale and BIPI creates a framework for collaborations of mutual interest that will move basic research in immunological and in cardiovascular diseases to applied technologies and therapies. It is governed by a joint steering committee that will approve collaborative projects between Yale and BIPI scientists funded under the approximately $1 million annual commitment.
A meeting of the joint steering committee was hosted by Yale to launch the alliance and review potential projects. The chosen projects include studies on the cytokine pathways in heart muscle cells and cells that line blood vessels, the identification of calcium channels in cells that mediate immunity, the protection of kidney blood vessels from hypertension and the therapeutic potential of the regulatory protein HIF-1a in the cardiovascular system.
Both the projects and the funding will be flexible and have two phases -- a one-year preliminary phase and a two-year expansion phase. Each research project will have two principal investigators, one each from BIPI and Yale.
Leaders of the alliance are Jordan S. Pober, professor of pathology, dermatology, and immunobiology at Yale, and Uwe Schoenbeck, vice president of cardiovascular disease research at BIPI. The alliance arose out of conversations between Pober and Carolyn Slayman, Sterling Professor of Genetics and deputy dean of the School of Medicine, and BIPI executives Schoenbeck; Mikael Dolsten, head of the Corporate Division Pharma Research; and Paul Anderson, senior vice president for research.
"This collaboration is to work on the scientific frontier together with Yale. It is something that we as a company believe is very important," says Dolsten. "Even as we come from various directions, we share the goal of trying to translate basic science to medical progress for the benefit of patients."
The new program enhances Boehringer Ingelheim's relationship with Yale research. For a number of years, BIPI has provided philanthropic support for both the School of Medicine and the Faculty of Arts and Sciences. The most significant gifts to date have been in support of the STARS (Science, Technology and Research Scholars) program, which has helped scores of students from underrepresented backgrounds excel in the sciences as undergraduates and prepare for careers in science and medicine.
In addition to Pober and Slayman, Yale representatives to the steering committee include Dr. Richard Flavell, Sterling Professor and chair of immunobiology and a Howard Hughes Medical Institute investigator; William Sessa, professor of pharmacology; and Dr. H. Kim Bottomly, professor of immunobiology and deputy provost for science, technology and faculty development.
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