 
Paul Greengard |
at event showcasing students' studies
Paul Greengard, a Nobel Prize-winning neuroscientist whose discoveries have provided a conceptual framework for the understanding of how the nervous system functions at the molecular level, will discuss his groundbreaking research at the School of Medicine's 15th annual Student Research Day on Friday, April 20.
His talk, the 2001 Farr Lecture, will highlight a day devoted to the original scientific research conducted by 50 medical students and public health students as part of their Yale training.
The day's events will begin at noon with a scientific poster session showcasing the results of these research projects in the corridors of the Jane Ellen Hope Building (JEH), 315 Cedar St. The public is invited to attend the poster session and lectures.
Five students whose research was selected for special honors by the Thesis Awards Committee will give oral presentations of their work at 2 p.m. in Rm. 110, JEH. The students, their degree programs and their research topics are: Michele Johnson (M.D.), "Genetic and Molecular Mechanisms of Autoimmune Lymphoproliferative Syndrome (ALPS)"; Kira Giovanelli (M.D.), "Central T Cell Tolerance in Murine Lupus"; Sharon Chekijian (M.D.), "Legal, Professional, Public and Policy Barriers to the Development of Organ Donation and Transplantation Programs in the Republic of Armenia"; Jonathan Erulkar (M.D.), "The Evaluation of OP-1 in a Rabbit Model of Posterolateral Fusion: A Biochemical, Histological and Radiographic Analysis"; and Geoffrey Emerson (M.D./Ph.D.), "Electrical Signaling Among Endo-thelial and Smooth Muscle Cells in Resistance Arteries."
At 4:30 p.m., Greengard will present the 15th annual Farr Lecture, which honors the late Dr. Lee E. Farr, a 1932 graduate of the School of Medicine. Greengard's topic will be "The Neurobiology of Dopamine Signaling." The talk will also take place in Rm. 110, JEH.
Greengard is the Vincent Astor Professor, head of the Laboratory of Molecular and Cellular Neuroscience and director of the Fisher Center for Research on Alzheimer's Disease at the Rockefeller University.
Over the last 30 years, he and his colleagues have developed a general model that provides a rational explanation, at the molecular and cellular levels, of the mechanism by which both electric and chemical stimuli produce physiological responses in individual nerve cells. Abnormalities in signaling by dopamine, a transmitter in the brain, are associated with several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder and substance abuse.
In addition to the 2000 Nobel Prize in Physiology or Medicine, Greengard has received numerous other awards and honors, including the 1991 National Academy of Sciences Award, the 1994 Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience and the 1997 Charles A. Dana Award for Pioneering Achievements in Health. He is a member of the American Academy of Arts and Sciences and senior member of the Institute of Medicine of the National Academy of Sciences.
Yale's medical school is the only one in the country that requires a dissertation based on original research for the M.D. degree, according to Dr. John N. Forrest Jr., professor of internal medicine and director of the Office of Student Research. The thesis has been considered an essential part of the Yale system of medical education since 1839, when the requirement was first instituted.
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