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Dr. Steven C. Hebert, newly named as the C.N.H. Long Professor of Cellular and Molecular Physiology, is one of the world's leading authorities on the kidney's regulation of potassium and other salts. His research has focused in part on the mechanisms and regulation of potassium, sodium and chloride transport by cells. He and his colleagues cloned two of the major genes involved in potassium transport by the kidney, a potassium channel known as ROMK and the Na-K-2C1 transporter. A mutation in either gene results in improper salt handling by the kidney and is a factor in end-stage renal disease and related disorders. His other major research focus is on the role of extracellular calcium as a "first messenger" regulating cell function. He and a colleague identified and cloned a G-protein-coupled receptor that plays an important role in maintaining intestinal health and reducing the risk of colon cancer. Hebert earned his B.A. at Florida State University and his M.D. at the University of Florida, and did his intern and residency work at the University of Alabama in Birmingham. He taught and served on hospital staffs in Alabama, Virginia and Texas before joining the faculty at Harvard Medical School. He served there 1984-1997, rising to the rank of professor and becoming director of the Laboratory of Molecular Physiology and Biophysics, Renal Division, at Brigham and Women's Hospital in Boston. He was the Ann and Roscoe R. Robinson Professor of Medicine, director of the Division of Nephrology, and professor of cell biology, pharmacology and molecular physiology and biophysics at Vanderbilt University Medical School 1997-2000. He is currently chair of Yale's Department of Cellular and Molecular Physiology and a professor in the Department of Internal Medicine (nephrology). Hebert's numerous honors include the Carl W. Gottschalk Award from the American Physiology Society in 1995 and the Homer W. Smith Award from the American Society of Nephrology and the New York Heart Association in 1997. He is the author of over 240 articles and book chapters; editor (with Dr. Robert Alpern) of "The Kidney: Physiology and Pathophysiology"; a former editor of the American Journal of Physiology; and a member of many editorial review boards.
He is also a founder and board member of two biotechnology companies, Marical Inc. (formerly AquaBio Products Sciences) and Pearl Development Group, both of Portland, Maine.
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