research on multiple sclerosis
A new Collaborative Multiple Sclerosis Research Center Award is bringing together Yale researchers from a variety of disciplines and viewpoints to focus on multiple sclerosis (MS) research.
The $825,000 grant from the National Multiple Sclerosis Society will foster integration of research among three established MS research laboratories at Yale and three renowned Yale scientists who are not currently active in MS research. The society has funded research at the Yale laboratories through peer review for several years.
The program is designed around the theme of central nervous system (CNS) damage and repair. In the past, much of Yale's MS research has been focused on repairing and rebuilding the myelin sheath that covers the spinal cord and is eroded by MS.
"The addition of three superb investigators eminent in their respective 'outside' fields will provide new approaches and expertise to address problems of MS research," says Jeffery Kocsis, professor of neurology and neurobiology, who heads one of the established MS programs. The other laboratory leaders are Nancy Ruddle, professor of epidemiology and public health and of immunobiology, and Dr. Stephen Waxman, chair of neurology.
The three scientists who will join the collaborative research program are Dr. Diane Krause, associate professor of laboratory medicine and pathology; Dr. Peter Creswell, professor of immunobiology, dermatology and cell biology; and Dr. Richard Flavell, Sterling Professor and chair of immunobiology.
Creswell, an expert in antigen presentation, will contribute to the study of CNS damage in the program. Krause, who is esteemed in the field of bone marrow stem cell biology and who also directs the Frisbee Laboratory at Yale, a clinical resource for human cell transplantation, will be an essential contributor to the study of CNS repair. The center will use animal models, including those developed and analyzed by Flavell, to test hypotheses related to clinical disease. Human applications will follow directly from the animal experiments and provide further direction for research.
Albert Lo, assistant clinical professor of neurology, will also be part of the research effort.
-- By Jacqueline Weaver
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