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June 25, 2004|Volume 32, Number 32|Four-Week Issue



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Study: Mammals' olfactory system
matures in different stages

Full development of the sense of smell in mammals is dependent on functional activity during critical periods in development, according to a study by researchers at Yale, Rockefeller and Columbia universities and published in the journal Science.

In mammals, the connection between odor and the brain occurs over a single nerve connection. The olfactory sensory neurons that have the same odorant receptor are directed to regions of the olfactory bulb, where they coalesce into a single structure, a glomerulus. This process is molecularly determined, but it remains controversial to what extent the process also relies on stimulation from the outside.

The visual system, it is known, develops initially without any functional activity, but is later refined and polished through sensory activity. Charles Greer, professor of neurosurgery, and his collaborators examined the postnatal formation of glomeruli in odor receptors M71 and M72 in gene-targeted mice during development to determine whether the same development process is found in the olfactory system.

The results of the study established four principles of olfactory system development -- without sensory activity there is no full maturation; there is a sensitive period during which activity influences the maturation of the organization; sensitive periods occur at different times for different olfactory receptors; and glomeruli may be innervated by more than one kind of sensory nerve during early development.

The lead author on the paper was Dong-Jing Zou of Columbia. Co-authors included Paul Feinstein and Peter Mombaerts of Rockefeller University; Aimee Rivers, Glennis Matthews, Ann Kim and Stuart Feinstein from Columbia.

-- By Jacqueline Weaver


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Alumni elect new trustee

Historian Blight to direct Gilder-Lehrman Center

Student's 'Ride to Endure' will raise funds for cancer group

ENDOWED PROFESSORSHIPS

Library acquires papers of famed poet Joseph Brodsky

IN FOCUS: F&ES-Anthropology Combined Degree

Troup students creating own plays in Drama School program

SCIENCE & MEDICAL NEWS

Committee reviewing employee health benefits . . .

Orchestral movement: Shinik Hahm leaving post . . .

Ranis and Hathaway to research international topics as Carnegie Scholars

I. Richard Savage dies; noted for applying statistics to public policys

Sundance Lab director named interim head of playwriting department

Campus Notes

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