 | Dr. Arthur L. Horwich |
A prominent Yale scientist will discuss his groundbreaking work on protein folding in cells as part of the School of Medicine's Student Research Day on Tuesday, May 10.
The annual event features a poster session and talks showcasing original research by medical school students. One highlight is a lecture honoring the late Dr. Lee E. Farr, a 1932 graduate of the School of Medicine. This year's Farr Lecturer will be Dr. Arthur L. Horwich, the Eugene Higgins Professor of Genetics and Pediatrics and a Howard Hughes Medical Institute investigator.
At Yale, students pursuing an M.D. degree are required to do a dissertation based on original research. In fact, the Yale School of Medicine is the only one in the country with such a longstanding requirement, according to Dr. John N. Forrest Jr., professor of medicine and director of the Office of Student Research.
This year, 72 students will share the results of their research in a poster session to be held noon-2 p.m. in the corridors of the Jane Ellen Hope Building (JEH), 315 Cedar St.
Five students have been chosen to give oral presentations about their work 2-4 p.m. in Rm. 110 of JEH. The first four are seeking M.D. degrees; the fifth, a combined M.D./Ph.D. degree. The students, their research projects and faculty advisers are:
Margo D. Simon, "HAART-Felt Prospects: Information, motivation, and behavioral skills regarding incipient highly active antiretroviral therapy among bilingual young adult students in Tugela Ferry, South Africa" with Dr. Gerald Friedland in the Department of Internal Medicine;
Eric Poolman, "Evaluating targeted ivermectin distribution for controlling river blindness" with Dr. Michael Cappello in the Department of Pediatrics;
Suzanne Baron, "Dual mechanisms regulating AMPK kinase action in the ischemic heart" with Dr. Lawrence Young in the Department of Internal Medicine;
Raymond Lynch, "Suppression of MHC class I and class II in trophoblast cells" with Dr. Graeme Hammond in the Department of Surgery; and
Joshua P. Klein, "On the function and survival of vasopressinergic neurons in diabetes" with Dr. Stephen Waxman in the Department of Neurology.
The above events are open to the public, free of charge.
Dr. Arthur Horwich will present the 18th annual Farr Lecture at 4:30 p.m. in Rm. 110 of JEH. This talk is also free and open to the public.
The Yale scientist is exploring the mechanism of action of molecular chaperones in assisting protein folding in the cell. He has investigated the role of ring assemblies called chaperonins in mediating adenosine triphosphate (ATP)-dependent folding of proteins to their native forms, as well as the mechanism of protein misfolding that results in the formation of amyloids -- fibrillar structures formed in a class of neurodegenerative diseases, including Alzheimer's disease.
To understand how these and related compounds work, Horwich employs genetic analysis in vivo, as well as biochemical analyses in vitro, in addition to crystallographic analyses, fluorescence and nuclear magnetic resonance spectroscopy studies. He has published his research in more than 100 articles or papers in scientific journals.
Horwich earned his B.A. and M.D. degrees from Brown University and completed a pediatric internship and residency at Yale-New Haven Hospital. From 1978 to 1981, he was a postdoctoral fellow at the Salk Institute in La Jolla, California, where he worked with Walter Eckhart and Tony Hunter. He returned to New Haven in 1981 as a postdoctoral fellow in the School of Medicine's Department of Genetics, where he worked with Dr. Leon Rosenberg. He joined the Yale faculty in 1984 as an assistant professor in genetics, and was named a full professor in that department in 1995. He has been affiliated with the Howard Hughes Medical Institute since 1990, and was named to the Higgins chair in 1993 -- the same year that he was elected to the National Academy of Sciences.
His other honors include the Society for Pediatric Research's Outstanding Young Investigator Award and the Protein Society's Hans Neurath Award. He has received a number of research awards, including the March of Dimes Basil O'Connor Starter Research Grant.
T H I S
Talk by Yale scientist to highlight
annual Student Research Day
Student presentations
Farr Lecture
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