Dr. Elizabeth B. Claus, associate professor in the Department of Epidemiology and Public Health at the School of Medicine, has been awarded a two-year $250,000 grant from the Susan B. Komen Foundation to study how outcomes for women diagnosed with a non-invasive form of breast cancer known as breast ductal carcinoma in-situ (DCIS) differ for those with and without mutations in BRCA1/2, two genes associated with an increased risk of breast and ovarian cancer.
At present, few women with DCIS have been tested for disease-associated mutations in BRCA1/2, although a recent study conducted by Claus and her colleagues found that women diagnosed with DCIS are as likely to carry mutations in BRCA1/2 as are women diagnosed with invasive breast cancer.
"The total number of women with DCIS and who have been found to have BRCA1/2 mutations is small and no one research center has a sufficient number of patients for study," says Claus.
In order to gather a group of female BRCA1/2 carriers diagnosed with DCIS, Claus plans to combine data from a number of other cancer centers -- including the University of Pennsylvania, Dana-Farber Cancer Institute and Memorial-Sloan Kettering -- in an effort to define preliminary estimates of outcome and to better define treatment goals for these women.
T H I SW E E K ' SS T O R I E S
Scientists identify new genus of monkey; first in 83 years
Divinity Dean reappointed to second term
Yale to celebrate 305th Commencement
Student photographs 'hidden beauty in everyday life'
Summertime at Yale
Brownell cited as one of world's '100 most influential people'
President Levin honored for increasing town-gown partnerships
ENDOWED PROFESSORSHIPS
Four individuals will bring their expertise . . . to SOM
Two noted violinists . . . join the faculty of the School of Music
Three residential college masters named to second term
Laura Cruickshank named to post of University planner
Exhibit features English silver pieces once owned by tsars
Exhibits look back at 40 years of chiming bells and more
Major renovation effort begins at Cross Campus Librar
MEDICAL SCHOOL NEWS
Eight graduating seniors are bound for China as teaching fellows
IN MEMORIAM
Yale's nurse-midwives celebrate 50 years of community care
Talk will focus on life extension and human right
'Keepers of the Dream' to look at advancing urban education
Sociologist Adams honored for book on 'The Familial State'
Association honors Yale-affiliated scientists and engineers . . .
Journal of Industrial Ecology marks two milestones . . .
Grant will fund research on how human speech is shaped
'Trouble in Tahiti' to be performed during School of Music alumni weekend
Campaign invites community to 'Plant a Row for the Hungry'
Campus Notes
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