 | The genome of the Neanderthals (skeleton on left) is being compared to that of homo sapiens using technology developed by the company 454 Life Sciences. |
The next program in the Yale BioHaven Entrepreneurship Seminar series on Wednesday, Nov. 8, will focus on 454 Life Sciences, a technology development subsidiary of the Branford, Connecticut-based biotechnology company CuraGen Corporation.
The seminar will take place from 3:30 to 5 p.m. in the School of Medicine's Anlyan Center auditorium, 300 Cedar St.
The speaker will be Christopher McLeod, president and chief executive officer of 454 Life Sciences. Established in 2000, the company develops and commercializes novel instrumentation and technology for conducting high-throughput nucleotide sequencing, with specific application to whole-genome sequencing and ultra-deep sequencing of target genes.
The hallmarks of 454 Sequencing™ are that it has simple, unbiased sample preparation and high capacity for parallel sequencing. This technology has dramatically increased the feasibility and lowered the cost of large-scale sequencing projects such as the initiative to analyze an individual human genome for $10,000.
The 454 Life Sciences instrumentation, the Genome Sequencer 20™ System, allows one individual to prepare and sequence an entire genome after performing a single sample preparation -- no matter the size of the genome studied. A single instrument using patented light-emitting sequencing chemistries produces sequence information at more than 60-times the capacity of instruments using the current technology.
In 2005, the company entered into an agreement with Roche for the promotion, sale and distribution of 454 Life Sciences' sequencing systems, including proprietary kits and reagents. 454 Sequencing™ is being used today by the Max Planck Institute to reconstruct the genome of the Neanderthal man, the Dana-Farber Cancer Institute and Broad Institute to detect cancer gene mutations, and the International Census of Marine Microbes to study microbial life in the world's oceans and its impact on ecosystems.
Refreshments will follow the seminar from 5 to 7 p.m. Registration is free, but those planning to attend must send advance notice to Larry Banks at larry.banks@yale.edu or the Yale Office of Cooperative Research at (203) 436-8096. Directions to the event are available on line at http://info.med.yale.edu/maps/cab.html.
Yale BioHaven Entrepreneurship Seminars are sponsored by the University's Office of Cooperative Research and Connecticut United for Research Excellence, and jointly promoted by Yale Entrepreneurial Society and Yale Biotechnology & Pharmaceutical Society. For further information on the seminar, contact Tracy Huang at (203) 785-3846 or tracy.huang@yale.edu.
T H I S
Seminar to focus on company's
genome sequencing technology
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