 
Paul Greengard |
at event showcasing student research
A talk by Nobel Prize-winning neuroscientist Paul Greengard will highlight the School of Medicine's Student Research Day on Thursday, May 2.
Greengard, whose discoveries have provided a conceptual framework for the understanding of how the nervous system functions at the molecular level, will deliver the 2002 Farr Lecture on the topic "The Neurobiology of Synaptic Transmission." His talk will take place at 4:30 p.m. in Rm. 110 of the Jane Ellen Hope Building (JEH), 315 Cedar St.
Greengard's talk will cap a day devoted to the original scientific research conducted by some 50 medical and public health students as part of their Yale training.
The day's events will begin at noon with a scientific poster session showcasing the results of these research projects in the corridors of JEH.
Five students whose research was selected for special honors by the Thesis Awards Committee will give oral presentations of their work beginning at 2 p.m. in Rm. 110 of JEH. The students, their degree programs and their research topics are: Felix Adler (M.D.), "Positional Cloning of a 9;13 Chromosomal Translocation Breakpoint Implicated in Hypophosphatemic Rickets"; Monica Lopez (M.D.), "Role for Sialic Acid in the Formation of Tight Lysosome-derived Vacuoles During Trypanosoma cruzi Invasion"; Prashanth Vallabhajosyula (M.D.), "Transcription Factor, XBP-1, is Essential for the Terminal Differentiation of B Cells Into Immunoglobulin Secreting Plasma Cells"; Emmanuelle Clerisme (M.D.), "Mechanism by which Estrogens Transcriptionally Repress the Expression of Cell Adhesion Molecules in Human Endothelial Cells"; and Wendy Garrett (M.D./Ph.D.), "The Regulation of Endocytosis in Developing Dentritic Cells."
Greengard's talk will follow refreshments at 4 p.m. in the JEH corridors. The neuroscientist had been scheduled to be last year's Farr Lecturer but was forced to postpone his Yale visit due to an injury.
Greengard is the Vincent Astor Professor, head of the Laboratory of Molecular and Cellular Neuroscience and director of the Fisher Center for Research on Alzheimer's Disease at the Rockefeller University. Over the last 30 years, he and his colleagues have developed a general model that provides a rational explanation, at the molecular and cellular levels, of the mechanism by which both electric and chemical stimuli produce physiological responses in individual nerve cells. Abnormalities in signaling by dopamine, a transmitter in the brain, are associated with several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder and substance abuse.
In addition to the 2000 Nobel Prize in Physiology or Medicine, Greengard has received numerous other awards and honors, including the 1991 National Academy of Sciences Award, the 1994 Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience and the 1997 Charles A. Dana Award for Pioneering Achievements in Health. He is a member of the American Academy of Arts and Sciences and senior member of the Institute of Medicine of the National Academy of Sciences.
Yale's medical school is the only one in the country that requires a dissertation based on original research for the M.D. degree, according to Dr. John N. Forrest Jr., professor of internal medicine and director of the Office of Student Research. The thesis has been considered an essential part of the Yale system of medical education since 1839, when the requirement was first instituted.
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