Donaghue grants announced
Three Yale scientists have received grants through the Ethel F. Donaghue Women's Health Investigator Program, part of Women's Health Research at Yale (WHR).
The recipients, who will all pursue innovative studies focusing on the health of women, are:
Akiko Iwaski, assistant professor in the Department of Epidemiology and Public Health. She will investigate gender differences in infection and immunity to genital herpes, one of the most common sexually transmitted diseases worldwide. Genital herpes is both more common and more severe in women than in men. Iwaski will study role of the HSV-2 virus that causes the disease. Her work will help further the design of preventative measures such as vaccines and anti-viral gels that are specifically tailored by gender.
Dr. Donna M. Neale, assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences. Neale will study how cells called trophoblasts affect preeclampsia, a disease unique to pregnancy. This disorder is heralded by the onset of hypertension after the 20th week of pregnancy and is one of the leading causes of maternal and infant death. Neale will look at the difference in trophoblast cells and the proteins in the blood of pregnant women with and without preeclampsia. This work could provide the basis for a screening test for the prediction of preeclampsia.
Julie K. Staley, assistant professor in the Department of Psychiatry. Staley will explore how the brain's nicotine receptors change with variations in ß-estradiol and progesterone levels in women who are non-smokers. The results from this research will guide future studies of women smokers and the severity of side-effects associated with cessation of smoking during different phases of the menstrual cycle in order to understand the biological mechanisms that would underlie smoking cessation treatments for women smokers.
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