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January 18, 2008|Volume 36, Number 15


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Ruslan M. Medzhitov



Medzhitov named first
incumbent of Wallace chair

Ruslan M. Medzhitov, who has been designated as the first David W. Wallace Professor of Immunobiology, has done pioneering work on the molecular mechanisms that drive the body’s immune response.

The new Wallace Professorship is one of five endowed chairs at the School of Medicine established by philanthropist and retired corporate executive David W. Wallace, a 1948 graduate of Yale’s School of Engineering, and his wife, Jean. The Wallaces were also major contributors to the renovation of Branford College.

Medzhitov was born in Tashkent, Uzbekistan, and earned a B.S. at Tashkent State University before going on to pursue a Ph.D. in biochemistry at Moscow University in 1990. At that time the Soviet Union was disintegrating and funding for science was drying up. Because laboratories were short of supplies, Medzhitov spent much of his time in the library, reading about modern biomedical science. There, he came upon a paper by Yale immunobiologist Charles Janeway (now deceased), who was studying how the innate immune system, an evolutionarily ancient system found in all multicellular animals, interacts with the adaptive immune system, found only in vertebrates.

Medzhitov wrote to Janeway and was accepted for postdoctoral study at Yale, arriving in 1994. The two researchers made the groundbreaking discovery that Toll-like receptors, a component of the innate system, provide the adaptive system with the necessary information to create custom-made B and T cells that target specific bacterial or viral invaders.

Today, Medzhitov’s laboratory is continuing to investigate the role of Toll-like receptors in how the innate immune system controls the adaptive system — particularly their role in autoimmune disorders, inflammation and allergy — with the goal of developing new strategies for vaccine design.

Since formally joining the Yale faculty in 1997 as an associate research scientist in the Section of Immunobiology, Medzhitov has risen through the ranks to become a full professor in 2003. In recognition of his seminal research, he was named a Howard Hughes Medical Institute investigator in 2000. This fall, he was one of the winners of the first New York Academy of Sciences Blavatnik Award for Young Scientists, and in 2006, he received the American Association of Immunologists-BD Bioscience Investigator Award for early-career researchers who have made outstanding contributions to the field of immunology.

His other honors include a Searle Scholarship and the Emil von Behring Award.


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